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Transitions™ - Research Citations

Black Cohosh

C. Brucker, C. Gorkow, K. Raus, and W. Wuttke, “First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055”, Menopause. 13(4), (2006), 678-691

C. Gorkow, D. Seidlová-Wuttke, W. Wuttke, “The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers”, Maturitas 44(1), (2003), S67-77

D. Cheema, A. Coomarasamy, T. El-Toukhy, “Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review”, Arch Gynecol Obstet 276(5), (2007), 463-9

E. Liske, and P. Wüstenberg, “Therapy of climacteric complaints with Cimicifuga racemosa: herbal medicine with clinically proven evidence [poster presentation]”, Menopause 5(4), (1998), 250

H. Boon, E. Guns, D. Oneschuk, R. Walji, J. Younus, “Black Cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients”, Suppor Care Cancer 15(8), (2007), 913-21

M. Birkhäuser, C.H. Bodmer, S. Frei-Kleiner, V.W. Rahlfs, W. Schaffner, “Cimicifuga racemosa dried ehtanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial”, Maturias 51(4), (2005), 397-404

MD. Eroglu, H. B. Karahan, E. Kuscu, Oktem, N. Taskintuna, and H. B.Zeyneloglu, “Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial”,  Adv Ther  24(2), (2007), 448-461

M. Friede, J. Freudenstien, H.H. Henneicke-von Zepelin, E. Liske, R. Osmers,  J. Schnitker, “Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms”, Obstet Gynecol 105(5), (2005), 1074-83

N. Acs, F. Banhidy, G. Vermes, “The effects of remifemin on subjective symptoms of menopause”, Adv Ther 22(2), (2005), 148-154

Rachel L Ruhlen, Edward R. Sauter, Grace Y. Sun, “Black Cohosh: Insights into its Mechanism(s) of Action”, Integrative Medicine Insights 3, (2008), 21-32

W. Bai,  L. Geng, H.H. Henneicke-von Zepelin, L. Hu, C. Jiao,  E. Liske, J. Liu, S. Wang, Z. Zhang, S. Zheng, “Efficacy and tolerabitliy of medicinal product containing an isoprpanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone”, Maturitas 58(1), (2007), 31-41


A. A. Silver, and John C. Krantz jr, "The Effect of the Ingestion of Burdock Root on Normal and Diabetic Individuals A Preliminary Report*", Annals of Internal Medicine 5(3), (1931), 274-284

Chen, Fu-An, An-Bang Wu, and Chau-Yang Chen, "The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components", Food Chemistry 86(4), (2004), 479-484

Lin, Chun-Ching, Jer-Min Lin, Jeng-Jer Yang, Shu-Chuan Chuang, and Takashi Ujiie, "Anti-inflammatory and radical scavenge effects of Arctium lappa", The American Journal of Chinese Medicine 24(02), (1996), 127-137

Chasteberry (Vitex)

C. Lauritzen, H.D. Reuter, R. Repges, “Treatment of premenstrual tension syndrome with Vitex angus castus: Controlled, double-blind study versus pyridoxine”, Phytomedicine 4(3), (1997), 183-189

D. Berger, W. Schaffner, E. Schrader, ”Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre- menstrual syndrome (PMS)”,  Arch Gynecol Obstet  264(3), (2000), 150-153

M. Albrecht, C. Peters-Welte, “Menstrual abnormalities and PMS. Vitex agnus-castus in a study of application”, Therapiewoche Gynakologie 7(1), (1994), 49-52

M Atmaca, S. Kumru, E. Tezcan, “Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder”,  Hum Psychopharmacol 18(3), (2003), 191-195

R. Schellenberg, “Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study”, BMJ 2001; 322(7279):134-137

S. Mills, S. Turner, “A double-blind clinical trial on a herbal remedy for premenstrual syndrome: a case study”, Complementary Therapies in Medicine 1(2), (1993), 73-77

Dong Quai (Angelica)

A.  Fugh-Berman, and F. Kronenberg, “Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials”, Ann Intern Med 137(10), (2002), 805-813

B. Kaplan, and C. Rotem, “Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study”, Gynecol.Endocrinol 23(2), (2007), 117-122

C. Breed, T.S. Hudson, L. Standish, “Clinical and endocrinological effects of a menopausal botanical formula”, J Naturopathic Med 7(1), (1998), 73-77

Dr. David Frawley and Dr. Vasant Lad, The Yoga of Herbs (Wisconsin: Lotus Press, 2001), 158-159.

J. R. Du, X. Kuang, Y. X. Liu, Z. M. Qian, C. Y. Wang, and Y. Yao,  “Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice”, Brain Res 1102(1), (2006), 145-153

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 225.

R. Fagot, B.Kaplan, C. Kupfersztain, and C. Rotem, “The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report”, Clin Exp Obstet.Gynecol (2003), 30(4), 203-206


B. K. Huang, L. Z. Huang, Q.Ye, and L. P. Qin, “Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus”, J Ethnopharmacol 133(1), (2011), 213-219

B.T. Gaffney, H.M. Hugel, P.A. Rich, “The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes”, Life Sci 70(4), (2001), 431-42

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 227.

I. J. Dionne, E. D. Goulet, “Assessment of the effects of eleutherococcus senticosus on endurance performance”, Int J Sport Nutr Exerc Metab 15(1), (2005), 75-83

H. D. Smolarz and D Zauski, “Eleutherococcus senticosus - an exemplary adaptogenic plant”, Postepy Fitoterapii Warszawa: Borgis Wydawnictwo Medyczne 9(4), (2008), 240-246

H. K.Chang, C. J. Kim, H. Kim, S. S. Kim, H. H. Lee, T. H. Lee,  Y. T. Rhim, M. C. Shin, , M. S. Shin, S. J. Yoon, “Effect of Acanthopanax senticosus on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats”, J Ethnopharmacol 114(1), (2007), 38-43

J. Daley, “Adaptogens”, J Complement Med 8(1), (2009), 36-38

K. I.  Block, T. Gochenour, C. Gyllenhaal, S. L. Merritt, and S. D. Peterson, “Efficacy and safety of herbal stimulants and sedatives in sleep disorders”, Sleep Med Rev 4(3), (2000), 229-251

L. R. Bucci, “Selected herbals and human exercise performance”, Am J Clin Nutr 72(2) (2000), 624S-636S

Ron Teeguarden, The Ancient Wisdom of the Chinese Tonic Herbs (New York: Warner Books, 1998), 111-119, 356.

S. Bentler, K. Brake,  Y. Butani,  M. Ernst A. J. Hartz, J. Hoehns, H. Kautzman, C. Logemann,  R. Noyes, S. Sinift, W. Wang, “Randomized controlled trial of Siberian ginseng for chronic fatigue”, Psychol.Med 34(1), (2004), 51-61

T. Deyama, S. Nishibe, and Y. Nakazawa, “Constituents and pharmacological effects of Eucommia and Siberian ginseng”, Acta Pharmacol Sin. 22(12), (2001), 1057-1070

Fo Ti Root

Dr. David Frawley and Dr. Vasant Lad, The Yoga of Herbs (Wisconsin: Lotus Press, 2001), 167-168

H. Choi,  S. C. Kang, J. H. Kwak, C. M. Lee, J. H. Lee, J. S. Oh, O. P. Zee, “Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities”, Phytother.Res  20(11), (2006),1017-1019

J. P. Chen, X. M.Liang,  S. X. Wang, C. Z. Zhang, Y. Zhang, “In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms”, J Ethnopharmacol  98(3), (2005), 295-300

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 229.

R. J Chang, M. Janfaza, Klein K. Oerter, J. A. Wong, “Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay”, J Clin Endocrinol.Metab 88(9), (2003), 4077-4079

Ron Teeguarden, The Ancient Wisdom of the Chinese Tonic Herbs (New York: Warner Books, 1998), 151-153.

Gamma Oryzanol

S. Hieda, M. Ishihara, Y. Ito, T. Maehama, T. Nakakita,  N. Ueno, K. Yamamoto,  “Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author's transl)”,  Nippon Sanka Fujinka Gakkai Zasshi 34(2), (1982), 243-251


H. A. Philp, “Hot flashes--a review of the literature on alternative and complementary treatment approaches”, Altern Med Rev 8(3), (2003), 284-302

H. Chiba, Y. Ishimi, K. Kanazawa, R. Masuyama, K. Suzuki,  M. Uehara, X. Wang, J. Wu, “Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice”, J Nutr 133(6), (2003), 1892-1897

L. M. Loscalzo, M. Marder, A. C. Paladini, C. Wasowski, “Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines”, Eur J Pharmacol 580(3), (2008), 306-313

S. L. Guzman-Gutierrez, and A. Navarrete, “Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers” Planta Med 75(4), (2009), 295-301

S. P. Fernandez, L. M. Loscalzo, M. Marder, M. C. Martinez, J. H. Medina, A. C. Paladini, H.Viola, C. Wasowski, “Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice”, Pharmacol.Biochem.Behav 92(2), (2009), 291-296

Z. Huang, F. Fang, J. Wang and C. W. Wong, “Structural activity relationship of flavonoids with estrogen-related receptor gamma”, FEBS Lett 584(1), (2010), 22-26

Kudzu Root (Puerari)

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 234.

V. Chandeying, S.  Lamlertkittikul, “Efficacy and safety of Pueraria mirifica (Kwao Kruea Khao) for the treatment of vasomotor symptoms in perimenopausal women: Phase II Stud”, J Med Assoc Thai 87(1), (2004), 33-40


Michael Tierra, The Way of Herbs (New York: Pocket Books, 1980), 158-159 .


Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 233.

M. R. Chen, R. Liang, X. Xu, “Effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage”, Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi 23(8), (2003), 593-595

Ron Teeguarden, The Ancient Wisdom of the Chinese Tonic Herbs (New York: Warner Books, 1998), 192-193, 234.

R. Y. Chan, N. Y. Ip,  D. M. Miller-Martini,  S. J. Sheu, Y. H. Wong, “A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine”, Phytother Res 15(6), (2001), 487-492

Poria Cocos ( Fu ling)

Jose-Luis Rios, “Chemical Constituents and Pharmacolgical Properties of Poria cocos”, Planta Med 77, (2011), 681-691

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 227.

Wild Yam

Dr. David Frawley and Dr. Vasant Lad, The Yoga of Herbs (Wisconsin: Lotus Press, 2001), 185-186.

T. Hudson, L. Standish, C. Breed, “Clinical and endocrinological effects of a menopausal botanical formula”, Journal of Naturopathic Medicine 7, (1997), 73-77


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