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Prostate-D™ - Research Citations


B.B. Aggarwal, H. Ichikawa, “Molecular targets and anticancer potential of indole-3-carbinol and its derivatives”, Cell Cycle 4, (2005), 1201–15

B.T.Ashok, V.P.S. Garikapaty, A. Mittelman, K. Tadi, R. K. Tiwari, “Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer”, Prostate 66, (2006), 453–62

D. Malejka-Giganti, D. R. Parkin,“Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol”, Cancer Detect Prev (2004), 28(1), 72-79

F. Ahmed, S. Ali, S. Banerjee, MM. Bhuiyan, Y. Li, FH. Sarkar and Z. Wang, “Down-regulation of androgen receptor by 3,3’-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells”, Cancer Res 66(20), (2006), 10064-72

K.J. Auborn, H.L. Bradlow, D. Sepkovic, S. Smith, “3,3′-Diindolylmethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells”,  Journal of Nutrition 138, (2008), 2379–2385

Leonard F. Bjeldanes, Gary L. Firestone, Hien T. Le, Charlene M. Schaldach, “Plant-derived 3,3’ –Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells”, The Journal of Biological Chemistry 278 (23), (2003), 21136-21145

L. F. Bjeldanes, G. H. Chang, Y. C. Chang, G. Firestone, B. C. Peng, J. Riby, “Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol” Biochem.Pharmacol 58(5), (1999), 825-834

L F. Bjeldanes, G.L. Firestone, Y. Gong, H. Sohn, L. Xue,  “3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells”,  Cancer Res 66(9), (2006), 4880-4887

Shilpi Rajoria, Robert Suriano, Andrea George, Arulkumaran Shanmugam, Stimson P. Schantz, Jan Geliebter, Raj K. Tiwari, “Estrogen Induced Metastitic Modulators MMP-2 and MMP-9 Are Targets of 3,3’ –Diindolylmethane in Thyroid Cancer”, PloS One 6(1), (2011), e15879

Green Tea

L. Jian, L. P. Xie, "Protective effect of green tea against prostate cancer: A case-control study in southeast China", International Journal of Cancer 108(1), (2004), 130-135

Naghma Khan, and Hasan Mukhtar, “Multitargeted Therapy of Cancer by Green Tea Polyphenols”, National Institutes of Health Cancer Letter 269(2), (2008), 269-280

R. Butler, A. G. Paschka, "Induction of apoptosis in prostate cancer cell lines by the green tea component, epigallocatechin-3-gallate", Cancer Letters 130(1–2), (1998), 1-7

S. Bettuzzi, M. Brausi, "Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study", Cancer Research 66(2), (2006), 1234-1240


Raymond C. Bergan, Rebecca L. Farmer, and Janet M. Pavese, “Inhibition of cancer cell invasion and metastasis by genistein”, Cancer Metastasis Rev 29, (2010), 465-482

Y. Chen, R. Dahiya, G. Deng, J. Liu, S. Majid, Y. Tanaka, MS. Zaman, “ MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer”, Cancer Prev Res (Phila) 4(1), (2011), 76-86

Vitamin D

Bio-Ying Bao, Huei-ju Ting, Jong-We Hsu and Yi-Fen Lee, “Protective role of 1α, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells”, Int J Cancer 122, (2008), 2699-2706

C. Garland, F. Garland, "Serum 25-Hydroxyvitamin D and Colon Cancer: Eight-Year Prospective Study”, The Lancet 334(8673), (1989), 1176-1178

D. E. Cole, H. M. Trang, "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2", Am J Clin Nutr 68(4), (1998), 854-858

G. Rammos, P. Tseke, "Vitamin D, the renin-angiotensin system, and insulin resistance", International Urology and Nephrology 40(2), (2008), 419-426

Hugo Van Baelen, Roger Bouillon, Marc De Maeyer,  Anja Rabijns,  Camiel De Ranter, Christel Verboven, “A structural basis for the unique binding features of the human vitamin D-binding protein”, Nature Structural Biology 9(2), (2002), 131-136

J. L. Anderson, H. T. May, "Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population", The American Journal of Cardiology 106(7), (2010), 963-968

J. Lau, A.G. Pittas, "The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis", Journal of Clinical Endocrinology & Metabolism 92(6), (2007), 2017-2029

J. Michael Gaziano, Edward L. Giovannucci, J. Bruce W. Hollis, David Hunter, Haojie Li, Jing Ma, Lorelei A. Mucci, Meir J. Stampfer, “A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer”, PLoS Medicine 4(3), (2007), 0562-0571

K. Helzlsouer, J.Tangrea, "Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men", Cancer Causes and Control 8(4), (1997), 615-625

L.A.G. Armas, J. Grote, R.P. Heaney, R.L. Horst, R.R. Recker, “Vitamin D3 is More Potent Than Vitamin D2 in Humans”, Journal of Clinical Endocrinology & Metabolism

Laura A.G. Armas, Robert P. Heaney, Bruce W. Hollis, “Vitamin D2 is much less effective than Vitamin D3 in Humans”, The Journal of Clinical Endocrinology and Metabolism 89(11), (2004), 5387-5391

Lisa A.Houghton, and Reinhold Vieth, "The case against ergocalciferol (vitamin D2) as a vitamin supplement", The American Journal of Clinical Nutrition 84(4), (2006), 694-697

M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease", Am J Clin Nutr 80(6), (2004), 1678S-1688S

M. F. Holick, "Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis", Am J Clin Nutr 79(3), (2004), 362-371

Michael F. Holick, “The Vitamin D Epidemic and its Health Consequences”, J Nutr 135, (2005), 2739S-2748S

M. J. Pencina, T. J. Wang, “Vitamin D Deficiency and Risk of Cardiovascular Disease", Circulation 117(4), (2008), 503-511

Robert P. Heaney, “Lessons for nutritional science from vitamin D”, Am J Clin Nutr 69, (1999), 825-6

Robert P. Heaney, “Vitamin D: Criteria for safety and efficacy”, Nutrition Reviews 66(2), (2008), S178-S181

R. P. Heaney, R. R. Recker, "Vitamin D3 Is More Potent Than Vitamin D2 in Humans" Journal of Clinical Endocrinology & Metabolism 96(3), (2011), E447-E452

U. A.Ajani, E. S. Ford, "Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults", Diabetes Care 28(5), (2005), 1228-1230

Y. Liel, E. Ulmer, "Low circulating vitamin D in obesity", Calcif Tissue Int 43(4), (1988), 199-201


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