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LifeEssence™ Powder - Research Citations

Alpha Lipoic Acid

L. Packer, E. H. Witt, "Alpha-lipoic acid as a biological antioxidant", Free Radical Biology and Medicine 19(2), (1995), 227-250


Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 223.

Beta Carotene

Cristina Palacios, "The role of nutrients in bone health, from A to Z", Critical Reviews in Food Science and Nutrition 46(8), (2006), 621-628

H. Sies and W. Stahl, "Antioxidant activity of carotenoids," Molecular Aspects of Medicine 24(6), (2003), 345-351

James Allen Olson, "Provitamin A function of carotenoids: the conversion of beta-carotene into vitamin A", The Journal of Nutrition 119(1), (1989), 105

Joseph L Napoli, and Kevin R. Race,"Biogenesis of retinoic acid from beta-carotene. Differences between the metabolism of beta-carotene and retinol", Journal of Biological Chemistry 263(33), (1988), 17372-17377

Mark Berneburg, Regina Goralczyk, Eicker, Jörg, Viola Kürten, Jean Krutmann, Georges Riss, and Susanne Wild, "Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation", Photochem. Photobiol. Sci. 2(6), (2003), 655-659

R. Blomstrand, Dew S. Goodman, Helen S. Huang, T. Shiratori and B. Werner, "The intestinal absorption and metabolism of vitamin A and beta-carotene in man", Journal of Clinical Investigation 45(10), (1966), 1615


A. Irwin, M.A. Kenney,  H. McCoy, C. Montgomery, R. Orell, L. Williams, “Relation of Boron to the composition and mechanical properties of bone”, Environ Health Perspect 102(7), (1994), 49-53

C.D. Hunt,”The biochemical effects of physiologic amounts of dietary boron in animal nutrition models”, Environ Health Perspect 102(7), (1994), 35-43

L. J. Taper, S. L. Volpe, "The relationship between boron and magnesium status and bone mineral density in the human: a review", Magnesium research: official organ of the International Society for the Development of Research on Magnesium 6(3), (1993), 291-296


J.A. Ho, I. W. Lu, M.C. Shieh, L. C. Wu, “Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts”,  J Agric Food Chem 53(10), (2005), 4207-4212

H. Inoue, K. Nakamura, S. Yamagishi, “Therapeutic potentials of unicellular green alga Chlorella in advanced glycation end product (AGE)-related disorders”, Med Hypotheses 65(5), (2005), 953-955

N. Hagino, and S. Ichimura, “Effect of chlorella on fecal and urinary cadmium excretion in "Itai-itai" disease”, Nippon Eiseigaku Zasshi 30(1), (1975), 77
R. A. Kay, “Microalgae as food and supplement”, Crit Rev Food Sci Nutr 30(6), (1991), 555-573

S. Otles, and R. Pire, “Fatty acid composition of Chlorella and Spirulina microalgae species”, J.AOAC Int. 84(6), (2001), 1708-1714


D. Bagchi, S. J. Stohs, "Cytotoxicity and oxidative mechanisms of different forms of chromium", Toxicology 180(1), (2002), 5-22

R. Shrivastava, R. K. Upreti, "Effects of chromium on the immune system", FEMS Immunology & Medical Microbiology 34(1), (2002), 1-7


J. Choi, H. J. Jung, W. T. Jung, K. T. Lee, J. H. Nam, and H. J. Park, “Structure of a new echinocystic acid bisdesmoside isolated from Codonopsis lanceolata roots and the cytotoxic activity of prosapogenins”,  J Agric Food Chem  50(15), (2002), 4190-4193

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 226.

Ron Teeguarden, The Ancient Wisdom of the Chinese Tonic Herbs (New York: Warner Books, 1998), 157-159, 358.

Y. Chen, N. Liang, J. Wei, Y. Zhu, “Chemical components of Codonopsis pilosula (Franch) Nannf. var volubilis (Nannf.) L.T. Shen”, Zhongguo Zhong.Yao Za Zhi 20 (10), (1995), 611-640


B. K. Huang, L. Z. Huang, L. P. Qin, Q.Ye, “Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus”, J Ethnopharmacol 133(1), (2011), 213-219

B.T. Gaffney, H.M. Hugel, P.A. Rich, “The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes”, Life Sci 70(4), (2001), 431-42

H. D. Smolarz and D Zauski, “Eleutherococcus senticosus - an exemplary adaptogenic plant”, Postepy Fitoterapii Warszawa: Borgis Wydawnictwo Medyczne 9(4), (2008), 240-246

H. K.Chang, C. J. Kim, H. Kim, S. S. Kim, H. H. Lee, T. H. Lee, Y. T. Rhim, M. C. Shin,  M. S. Shin, and S. J. Yoon, “Effect of Acanthopanax senticosus on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats”, J Ethnopharmacol 114(1), (2007), 38-43

I. J. Dionne, E. D. Goulet, “Assessment of the effects of eleutherococcus senticosus on endurance performance”, Int J Sport Nutr Exerc Metab 15(1), (2005), 75-83

J. Daley, “Adaptogens”, J Complement Med 8(1), (2009), 36-38

K. I.  Block, T. Gochenour, C. Gyllenhaal, S. L. Merritt, and S. D. Peterson, “Efficacy and safety of herbal stimulants and sedatives in sleep disorders”, Sleep Med Rev 4(3), (2000), 229-251

L. R. Bucci, “Selected herbals and human exercise performance”, Am J Clin Nutr 72(2) (2000), 624S-636S

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 227.

Ron Teeguarden, The Ancient Wisdom of the Chinese Tonic Herbs (New York: Warner Books, 1998), 111-119, 356.

S. Bentler, K. Brake,  Y. Butani,  M. Ernst A. J. Hartz, J. Hoehns, H. Kautzman, C. Logemann,  R. Noyes, S. Sinift, W. Wang, “Randomized controlled trial of Siberian ginseng for chronic fatigue”, Psychol.Med 34(1), (2004), 51-61

T. Deyama, S. Nishibe, and Y. Nakazawa, “Constituents and pharmacological effects of Eucommia and Siberian ginseng”, Acta Pharmacol Sin. 22(12), (2001), 1057-1070

Goji fruit

H. K. Kim, H. P. Kim, J. Kim, S. Y. Kim, Y. C. Kim, Y. C.  Kim, E. J. Lee, J. H. Park, “Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats”,  Biol Pharm Bull 25(3), (2002), 390-392

H. P. Kim, S. Y. Kim, Y. C.  Kim, and Y. C. Kim, E. J. Lee, “Zeaxanthin dipalmitate from Lycium chinense has hepatoprotective activity”, Res Commun.Mol.Pathol Pharmacol 97(3), (1997), 301-314

Michael Tierra, Planetary Herbology (Twin Lakes: Lotus Press, 1988)

R. C. Chang, C. M. Che, S. W. Lai, S. K. Leung, K. F. So, M. S. Yu, W. H. Yuen, S. Y. Zee, “Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity”,  Exp Gerontol   40(8-9), (2005), 716-727

Z. H. Jiang, K. S. Leung, Y.Li, C. Ma, Y. Peng, Z. Zhao, “Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii)”,  Plant Foods Hum.Nutr 60(4), (2005), 161-164


H. Bai, B.W. Liu, R. Liu, Y. Liu, F. Meng, “Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+”, Zhong.Yao Cai. 30(6), (2007), 677-681

T. L. Cirico, and S. T. Omaye, “Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation”, Food Chem Toxico 44(4), (2006), 510-516


Erin K. Ceaser, Dale A. Dickinson, Aimee Landar, Anna-Liisa Levonen, Jason D. Morrow, Anup Ramachandran, Victor M. Darley-Usmar, and Giuseppe Zanoni", Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products." Biochemical Journal 378(2), (2004), 373


M. A. Beilke, C. Collins-Lech, and P. G. Sohnle, “Effects of dimethyl sulfoxide on the oxidative function of human neutrophils”, J Lab Clin Med 110(1), (1987), 91-96


G. Atmaca, “Antioxidant effects of sulfur-containing amino acids”, Yonsei Med J 45(5), (2004), 776-88

S. Parcell, “Sulfur in human nutrition and applications in medicine”, Altern Med Rev 7(1), (2002), 22-44

Poria Cocos (Fu ling)

Jose-Luis Rios, “Chemical Constituents and Pharmacolgical Properties of Poria cocos”, Planta Med 77, (2011), 681-691

Michael Tierra, The Way of Herbs, (New York: Pocket Books, 1980), 227.


A. Crozier, B. Daneshvar, L. O. Dragsted, J. Haraldsdottir, P. Knuthsen,  S.T.  Lauridsen, S. E. Nielsen, B. Sandstrom and J. F. Young, “Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status”, Am J Clin.Nutr  69(1), (1999), 87-94

B. Stavric, “Quercetin in our diet: from potent mutagen to probable anticarcinogen”, Clin.Biochem 27(4), (1994), 245-248

W. J. Angerson, M. E. Lean, and M .Noroozi, “Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes”, Am J Clin Nutr  67(6), (1998), 1210-1218


A.M. Gouny, P Gouny, D. Horovitz, “Effectiveness and safety of hydroxyethyl-rutosides in the local treatment of symptoms of venous insufficiency during air travel”, J Mal Vasc 24(3), (1999), 214-220

G. Hennings, W. Nocker, D Rehn, “Time course of the anti-oedematous effect of O-(beta-hydroxyethyl)-rutosides in healthy volunteers”, Eur J Clin Pharmacol 40(6), (1991), 625-627

Selenium (L-methyl selenocysteine)

J. Liu, G. Luo, “Selenoproteins and Thyroid Cancer:
Selenoproteins and Mimics”, Springer Berlin Heidelberg, (2012), 173-182

P. D. Whanger,”Selenium and its relationship to cancer: an update”, British Journal of Nutrition, 91, (2004), 11-28

P.D. Whanger, “Selenocompounds in Plants and Animals and their Biological Significance”, J Am Coll Nutr 21(3), (2002), 223-232

Silica-rich bamboo leaf-Silicon
R. Jugdaosingh, “Silicon and Bone Health”, J Nutr Health Aging 11(2), (2007), 99-110

Vitamin B12 Methylcobalamin

R.A.S. Hemat, Principles of Orthomolecularism (Urotext, 2004), 233.

Sareen S. Gropper and Jack L. Smith, Advanced Nutrition and Human Metabolism (Belmont,CA: Wadsworth, 2005), 356.

Vitamin C

H. Padh, "Vitamin C: Newer Insights into Its Biochemical Functions", Nutrition Reviews 49(3), (1991), 65-70

Lester Packer, “Vitamin C in health and disease”, CRC 5, (1997)

Vitamin D

Bio-Ying Bao, Huei-ju Ting, Jong-We Hsu and Yi-Fen Lee, “Protective role of 1α, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells”, Int J Cancer 122, (2008), 2699-2706

C. Garland, F. Garland, "Serum 25-Hydroxyvitamin D and Colon Cancer: Eight-Year Prospective Study”, The Lancet 334(8673), (1989), 1176-1178

D. E. Cole, H. M. Trang, "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2", Am J Clin Nutr 68(4), (1998), 854-858

G. Rammos, P. Tseke, "Vitamin D, the renin-angiotensin system, and insulin resistance", International Urology and Nephrology 40(2), (2008), 419-426

Hugo Van Baelen, Roger Bouillon, Marc De Maeyer, Anja Rabijns,  Camiel De Ranter, Christel Verboven, “A structural basis for the unique binding features of the human vitamin D-binding protein”, Nature Structural Biology 9(2), (2002), 131-136

J. L. Anderson, H. T. May, "Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population", The American Journal of Cardiology 106(7), (2010), 963-968

J. Lau, A.G. Pittas, “The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis", Journal of Clinical Endocrinology & Metabolism 92(6), (2007), 2017-2029

J. Michael Gaziano, Edward L. Giovannucci, J. Bruce W. Hollis, David Hunter, Haojie Li, Jing Ma, Lorelei A. Mucci, Meir J. Stampfer, “A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer”, PLoS Medicine 4(3), (2007), 0562-0571

K. Helzlsouer, J.Tangrea, "Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men", Cancer Causes and Control 8(4), (1997), 615-625

L.A.G. Armas, J. Grote, R.P. Heaney, R.L. Horst, R.R. Recker, “Vitamin D3 is More Potent Than Vitamin D2 in Humans”, Journal of Clinical Endocrinology & Metabolism

Laura A.G. Armas, Robert P. Heaney, Bruce W. Hollis “Vitamin D2 is much less effective than Vitamin D3 in Humans”, The Journal of Clinical Endocrinology and Metabolism 89(11), (2004), 5387-5391

Lisa A.Houghton, and Reinhold Vieth, "The case against ergocalciferol (vitamin D2) as a vitamin supplement", The American Journal of Clinical Nutrition 84(4), (2006), 694-697

M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease", Am J Clin Nutr 80(6), (2004), 1678S-1688S

M. F. Holick, "Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis", Am J Clin Nutr 79(3), (2004), 362-371

Michael F. Holick, “The Vitamin D Epidemic and its Health Consequences”, J Nutr 135, (2005), 2739S-2748S

M. J. Pencina, T. J. Wang, “Vitamin D Deficiency and Risk of Cardiovascular Disease", Circulation 117(4), (2008), 503-511

Robert P. Heaney, “Lessons for nutritional science from vitamin D”, Am J Clin Nutr 69, (1999), 825-6

Robert P. Heaney, “Vitamin D: Criteria for safety and efficacy”, Nutrition Reviews 66(2), (2008), S178-S181

R. P. Heaney, R. R. Recker, "Vitamin D3 Is More Potent Than Vitamin D2 in Humans" Journal of Clinical Endocrinology & Metabolism 96(3), (2011), E447-E452

U. A.Ajani , E. S. Ford, "Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults", Diabetes Care 28(5), (2005), 1228-1230

Y. Liel, E. Ulmer, "Low circulating vitamin D in obesity", Calcif Tissue Int 43(4), (1988), 199-201

Vitamin E, Mixed Tocopherols

H. N. Bhagavan, and R. K. Chopra, "Relative bioavailabilities of natural and synthetic vitamin E formulations containing mixed tocopherols in human subjects", International Journal for Vitamin and Nutrition Research 69(2), (1999), 92-95

J. Ju, H. J. Lee, "Mixed Tocopherols Prevent Mammary Tumorigenesis by Inhibiting Estrogen Action and Activating PPAR-γ", Clinical Cancer Research 15(12), (2009), 4242-4249

K. Saldeen, and T. Saldeen, "Importance of tocopherols beyond α-tocopherol: evidence from animal and human studies", Nutrition Research 25(10), (2005), 877-889

M. Liu, R. Wallin, "Mixed Tocopherols Have a Stronger Inhibitory Effect on Lipid Peroxidation Than [alpha]-Tocopherol Alone", Journal of Cardiovascular Pharmacology 39(5), (2002), 714-721

N. C. Ward, J. H. Y. Wu, (2007), "Effects of α-Tocopherol and Mixed Tocopherol Supplementation on Markers of Oxidative Stress and Inflammation in Type 2 Diabetes", Clinical Chemistry 53(3), 511-519

Vitamin K1

N. Ibarrola-Jurado, J. Salas Salvadó, “Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease”, Am J Clin Nutr, (2012)

Vitamin K2

T. Sato, L.J. Schurgers, K. Uenishi, “Comparison of menaquinone-4 and menaquinoine-7 bioavailability in healthy women”, Nutrition Journal 11, (2012), 93


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